Can manipulation of the immune system affect the course of cancer? This “masterly” history of immunotherapy describes efforts by scientists to use the immune system to treat cancer. The narrative, “as gripping as a spy thriller” (Kirkus Reviews), ranges from the 19th century use of “Coley’s toxins” through the development of immune-based drugs like interferon. The background history of monoclonal antibody drugs like Rituxan and modern cancer vaccines is “an example of science journalism at its best” (Science).

“Rarely is one privileged with such a view—neither jaundiced nor wide-eyed but clear and insightful.” – Jerome Groopman